- Good range of bacteria
- Includes vital enzymes
- Focuses on fat and protein digestion
- Green tea does help with fat loss
- Very expensive for what it is
- Most of the bacteria and enzymes in here are transient
- Not a permanent fix for gut health
- Slimaluma may cause side effects
- Not suitable for people with weakened immune system
Nucific Bio X4 is a fairly good probiotic. It contains some good digestive enzymes and some really beneficial bacteria. When taken together, these substances will improve gut microbiome health, which will in turn improve cognitive function, mood, physical performance, and overall health. We do recommend using a prebiotic rather than a probiotic, but Bio X4 is a great probiotic for sure. The only big downside is the price tag – $100 for a single bottle is extremely expensive for a probiotic!
Nucific Bio X4 Review: Does this probiotic help with weight loss?
Nucific Bio X4 is making a lot of noise in the supplement industry right now. It is one of the best-selling probiotics on the market. Given the popularity of probiotics right now, that’s really saying something!
So what does Nucific Bio X4 do? Why is it so popular right now?
According to the Nucific website, Bio X4 is a natural probiotic weight loss supplement.
The main sales page lists the following key benefits that users can expect from Bio X4:
- Reduced food cravings
- Faster metabolism
- Facilitates smoother digestion
- Promotes weight loss
Weight loss is not the main reason that people usually use probiotics. Normally it’s to promote overall good health, or to improve cognitive function (via the gut-mind axis).
Nucific Bio X4 isn’t the only gut health
supplement promising to help with weight management, but these kinds of probiotics aren’t typical.
If Nucific Bio X4 can really deliver on these promises, then it will turn out to be one great probiotic.
So, does it? Does Nucific Bio X4 work? Is it really safe for long-term use? What ingredients does it use? Are there better ways to promote a healthy gut microbiome? Find out by reading our detailed Nucific Bio X4 review below!
Nucific Bio X4 Ingredients
The main question people ask about Nucific Bio X4 is; what is in this probiotic?
Here is the Bio X4 ingredients list as it appears on the bottle:
Here is a list of each individual ingredient:
- L. acidophilus
- L. rhamnosus
- L. plantarum
- B. lactis
- B. animalis
- Green tea extract
We’ll now give you a brief overview of what each blend does and how it contributes to better gut health. We will tell you whether or not we think the ingredient actually works, and what the scientific evidence has to say. Please post any questions you have in the comments section at the end.
Bio X4 Probiotic Blend – 4 Billion CFU
The Bio X4 probiotic blend contains 5 extremely important species of bacteria. These are:
- L. acidophilus
- L. rhamnosus
- L. plantarum
- B. lactis
- B. animalis
The lactobacillus genus species – those with the L. prefix – are extremely beneficial to gut health, and to bodily health more generally.
L. acidophilus is found in the large intestine and produces lactic acid. L. rhamnosus is used to treat a variety of bacterial infections (stemming from imbalances), although it is thought to be a transient rather than indigenous bacteria. While L. rhamnosus is widely used a probiotic, it might cause problems in people with a weakened immune system.
L. plantarum is a bacteria commonly found in fermented foods. It has one of the largest genomes of the lactic acid-producing bacteria, and is a very flexible and versatile species.
B lactis can be found throughout the human long and short intestines. It is an extremely powerful, but transient, bacteria. Studies have shown that B. lactis consumption improves digestion, decreases lactose intolerance, reduces constipation, and might even promote a healthy immune system. All good probiotics contain B. lactis, and Bio X4 no doubt has plenty.
B. animalis has been used as a probiotic for a long time, particularly for the treatment of IBS and diarrhea. It is thought to rapidly restore normal gut flora.
Digestive Enzyme Blend – 43mg
The Bio X4 digestive enzyme blend contains three important probiotic ingredients. These are:
These enzymes are among the most important in the human digestive process. Without these enzymes – or sufficient amounts of them – you will encounter serious digestive problems.
Amylase is found in both saliva and pancreatic fluid. Its job is to break down starch and glycogen into more simple sugars (maltose). You can see amylase in action when you chew complex carbs; amylase will slowly make wheat taste sweet the more you chew! Bio X4 should therefore help with carb processing.
Bromelain is not an autochonous human digestive enzyme. Rather, it is found in high concentrations in pineapples. Bromelain breaks down proteins, and it is said to be a natural anti-inflammatory. As such, it is sometimes used to relieve sinus problems as well as to aid digestion.
Lipase is a protein made in the pancreas. It breaks down fats. More specifically, it catalyzes the hydrolysis of fats. Humans produce lots of different types of lipase, which all perform distinct functions. Lipase is typically used to make yogurt and cheese, and it is a common ingredient in probiotics like Bio X4.
Weight Management Blend – 100mg
The “weight management blend” contains nothing but green tea extract. Studies have found that green tea extract promotes fat loss. A catechin in green tea called EGCG stimulates lipolysis independently of exercise and diet. Nucific state on the label that 50% of the green tea extract in Bio X4 is EGCG, which is fantastic.
Craving Control Blend – 166mg
Slimaluma is a branded extract from Caralluma Fimbriata; an edible cactus native to India. It is commonly eaten right across the Indian subcontinent. It has been particularly sought-after for its ability to suppress appetite; very useful during the past when hunting was still common.
Few studies have been published on Slimaluma, so we cannot say for certain whether the extract is safe and well tolerated.
Note about Bio X4 doses
When you’re dealing with probiotics like Nucific Bio X4, then the doses are not particularly important. The exact number of viable bacteria cells – represented by CFU count – in a sample will usually be in the billions. Bacteria tend to multiple quickly, so a variance of a few billion makes little difference. The same goes for enzymes, although with these the dose is more important.
Our thoughts on the Nucific Bio X4 formula
Nucific Bio X4 looks like a very good probiotic supplement.
Nucific have certainly put together quite a combination of ingredients.
Bio X4 contains many of the most important genus of bacteria. When consumed together like this, they will no doubt combat diarrhea, reduce constipation, and improve digestive health more generally.
The transient bacteria in Bio X4 will help you digest food and make nutrient absorption more efficient.
Consuming the enzymes in Bio X4 will help you break down carbohydrates and fats much easier.
The fact that Bio X4 uses bromelain – which helps break down protein – is a nice bonus. Few probiotics utilize bromelain, but it can make a big difference (especially if you consume a lot of protein).
Together, these substances can replenish healthy gut flora, support the growth of beneficial gut bacteria, and reduce the symptoms of digestive stress (lactose intolerance, IBS, etc).
When you start healing your gut microbiome, you will almost always experience drastic improvements in overall health and performance.
A healthy gut microbiome will also help with body composition. You will find it much easier to lose fat and keep fat off if your gut microbiome is in top condition. However, all probiotics support weight loss in this way, so it isn’t necessarily fair of Bio X4 to claim to be a weight loss supplement.
We think it’s fair to say that Nucific Bio X4 works. It is a good probiotic supplement, capable to supporting digestive health, cognitive performance, and weight management.
If you are looking to optimize your gut microbiome, and we think everybody should, then Nucific Bio X4 is not a bad option. That said, we still think most people will benefit more from a good pre-biotic such as Performance Lab Prebiotic.
Does Bio X4 help you lose weight?
Bio X4 is a probiotic. It is designed first and foremost to support a healthy gut microbiome and to fix any digestive issues related to bacteria/enzyme imbalances.
However, unlike many probiotics, Nucific sell Bio X4 as a weight loss probiotic.
Probiotics will help with body composition. As they improve digestion of food and the breakdown of fats, they can significantly increase how satisfied you are after eating.
Bio X4 also contains some substances specifically designed to promote weight loss.
Green tea extract is an effective weight loss aid. A catechin in green tea called EGCG has been found to stimulate fat loss, especially in overweight individuals.
The green tea extract in Bio X4 is extremely rich in EGCG – 50% by weight. That is more than enough for it to have an effect on your body fat levels.
The Slimaluma may well turn out to be an effective appetite suppressor. However, it is pretty much untested in clinical conditions. We haven’t seen a conclusive clinical trial in which caralluma fimbriata has made a meaningful difference to appetite.
On the whole though, we think Bio X4 will help you lose weight just like every other decent probiotic, or every other good quality gut health supplement for that matter. Using a probiotic like Bio X4 is certainly a more reliable, safer alternative to diet pills.
Side Effects – Is Nucific Bio X4 safe?
Probiotics are considered generally safe for healthy adults. They do not regularly cause side effects.
Any side effects experienced while using probiotics tend to be mild and short-lived. The most common side effects people experience with probiotics is bloating, gas, and mild stomach cramps. This is fairly normal as your gut microbiome begins to change.
These are ironically the same problems people encounter when they have an unhealthy or imbalanced gut microbiome!
The only concerns relate to people with pre-existing medical conditions.
In rare cases of severely weakened immune systems, one of the bacteria in Bio X4 – L. rhamnosus – may cause endocarditis. This is when the inner wall of the heart becomes inflamed due to bacterial infection. There are also some documented cases of sepsis resulting from L. rhamnosus use.
However, these cases are extremely rare. If you do not have a severely weakened immune system, you should be fine!
What about the other ingredients in Nucific Bio X4?
High doses of EGCG have been found to be very well tolerated. None of the studies looking at large doses of high-EGCG green tea extracts reported side effects.
Trials looking at caralluma fimbriata report only mild side effects. These trials lasted around 12 weeks on average, and reported side effects ranging from nausea and constipation to heart palpitations.
Bio X4 reviews & complaints
It’s worth taking a look at the many Nucific Bio X4 reviews online.
There are dozens of Bio X4 reviews on the internet; both on the official Nucific website, on gut health blogs, and on supplement review sites.
It’s not surprising that reviews of a high quality probiotic like Bio X4 are overwhelmingly positive.
Here is what some Bio X4 users have to say about this probiotic!
Sarj is a verified customer – according to Nucific – and he loved Bio X4:
“I’ve been taking BIOx4 for almost a month now. I haven’t seen any weight loss and I still have cravings for sweets but it has curbed my appetite. The most obvious plus is that it’s made me more regular and I do have more energy. I will continue to take it and hoping to see some weight loss in the next month.”
Christine Spring – another “verified reviewer” – had this to say:
“I have been using Bio-X4 for 30 days. The first thing I noticed was that I no longer had sweet cravings. The second thing I noticed was that my tummy was flatter. The scale revealed 6 pounds down and that is something that I have been able to do in almost 5 years. I am very happy with this product.”
Of course, all of the reviews of Bio X4 on the Nucific website are positive. However, not all customers were this happy.
There are other, less enthusiastic Bio X4 reviews online.
You will find Bio X4 complaints on several different forums dedicated to health and biohacking, and on the BBB website.
Most of the complaints about Nucific Bio X4 relate to over-charging, failed deliveries or refused returns. This is normal for a big company though.
In Conclusion – Does Nucific Bio X4 really work?
We think Nucific Bio X4 looks like a very good probiotic supplement.
It contains a very sensible blend of digestive enzymes, gut-friendly bacteria, and a high-EGCG green tea extract to facilitate fat loss.
Improving your gut microbiome health invariably improves several different aspects of health and performance. Your gut health affects everything from your cognitive performance to your immune system function.
In supporting a healthy gut microbiome, Nucific Bio X4 will improve mental functioning, physical performance, and overall health.
Your gut even has a profound effect on your mood and mental health – looking after it is a good idea!
In terms of weight loss, we think Bio X4 could be better. Apart from the green tea extract, it doesn’t offer anything that any good probiotic doesn’t. We don’t know if Bio X4 should be sold as a weight management supplement.
It is also very expensive for a probiotic. A single bottle costs $100, which is steep by industry standards. But as always, you get what you pay for!
But it is a great probiotic; no doubt about that. Nucific Bio X4 represents good value for money and it has plenty of positive reviews.
We still recommend using a prebiotic rather than a probiotic. But if you are already using a prebiotic, then adding in Bio X4 might be a great idea. If you can afford the $100 price tag that is!
Is Bio X4 a scam?
No, Bio X4 is not a scam. Not even close. Nucific are a highly reputable supplement manufacturer. They have a very honest returns policy. Bio X4 is used by thousands of people across the US, and the vast majority of them are satisfied customers. The only complains on the Nucific website relate to over-charging; this seems to be extremely rare and Nucific always respond quickly.
There are some Bio X4 scams out there though. You will find some products being sold on Amazon which are designed to look like Nucific Bio X4. They might even be called Bio X4. But they are not Nucific brand; they are low quality rip-offs. Always make sure you’re buying the exact product you’re looking for!
Can you buy Bio X4 at Walmart?
As far as we’re aware, Bio X4 is only sold online. You can only buy Bio X4 through the Nucific website. As we said above, buying from third-parties can open you up to scams.
Is there a Bio X4 free trial?
Nucific Bio X4 is not available on a free trial. However, Nucific do offer a 90 day money back guarantee. To our knowledge, they do honor this guarantee so long as you meet their terms and conditions.
Does Bio X4 need to be refrigerated?
No, Bio X4 does not need to be refrigerated.
Can you take Bio X4 without food?
Yes, you can, but you will not get optimal results unless you take Bio X4 with food. For best results, take 1 capsules of Bio X4 three times per day with food. The timing doesn’t matter.
Is this the same as Biox4?
You’ll often see people refer to BioX4. This is just another way to write Nucific Bio X4 – they are talking about the same product. There might be some other prebiotics, probiotics or weight loss supplements out there calling themselves Biox4. Make sure the prebiotic you’re looking at is by Nucific!
Brian Johnson is a former academic researcher, psychologist, and tireless proponent of bio-hacking. Brian has dedicated all of his time since leaving academia and private practice to promoting the benefits to be obtained from the application of biotechnology and bio-hacking supplements. He has years of experience with nootropics, as well as prebiotics, probiotics, and other natural nutritional supplements. He has published scholarly research on natural nootropics; you can find his papers on his Google Scholar page.